Born in Udine, Afro first showed his work when he was sixteen, alongside the paintings of his artist brothers, Dino and Mirko (it). Two years later he and Dino won a scholarship to study art in Rome under a stipend from the Marangoni Arts Foundation in Udine.
By 1933 he was exhibiting, along with fellow Friulians Bosisio, Pittino e Taiuti, at the Galleria del Milione in Milan. In 1935 he participated in the Rome Quadriennale art exhibition, and he showed his work several times at the Venice Biennale. Afro followed the School of Rome, creating murals. In 1936, he receives a commission to paint for the Udine opera house. In 1937, collaborating with Corrado Cagli, he works on large murals for the World Exhibition held in Paris.
In 1950, he travelled to New York City, and began a twenty-year collaboration with the Catherine Viviano Gallery. Dore Ashton wrote about Afro in 1955 in Art Digest: “Like most Italians, Afro knows how to celebrate. The fanciful, ebullient side of his nature emerges in the high-keyed recent paintings—those in which he allowed himself the most freedom and spontaneity to date. In these, he celebrates the delights of senses”.
Afro was shown in an exhibition called The New Decade: 22 European Painters and Sculptors, which toured the United States. His work was included at documenta 1 in Kassel, Germany. Afro aligns with Moreni, Corpora, Morlotti, Birolli, Santomaso, Turcato and Vedova, previous members of the "Fronte nuovo delle Arti", together they form the "Gruppo degli Otto" (Group of Eight).By the mid-1950s Afro's art was obtaining worldwide reputation, and he received the honor of Best Italian Artist at the 1956 Venice Biennale. In 1957, he was recruited to teach for eight months at Mills College in Oakland, California. While artist-in-residence at the school he made a mural for the UNESCO headquarters in Paris. It was titled The Garden of Hope and was included amongst works by Appel, Arp, Calder, Matta, Miró, Picasso and Tamayo at UNESCO.Wikipedia