The sister of better known artist Margaret MacDonald, she was born near at Tipton, near Wolverhampton, and moved to Glasgow with her family in 1890. Both sisters enrolled in painting classes at the Glasgow School of Art in 1891, where they met the architect Charles Rennie Mackintosh and artist Herbert MacNair.Frances went on to marry MacNair, and Margaret married Mackintosh. All four later became the loose collective of the Glasgow School known as "The Four".
Frances' achievements are less well known than those of her sister, due in part to her departure from Glasgow, but also because her husband destroyed many of her works after her death. Both sisters works were also frequently overshadowed by the achievements of Charles Rennie Mackintosh. Frances died in Glasgow in 1921.
Much of her work that remains is held by the Hunterian Museum and Art Gallery, and in the Walker Art Gallery in Liverpool.Wikipedia