Born in Santiago de los Caballeros, she initially studied art under Yoryi Morel in his academy in that city. Ledesma later enrolled in the National School of Fine Arts in Santo Domingo, graduating in 1948. Her professors included Celeste Woss y Gil and George Hausdorf, while her primary mentor was painting professor Josep Gausachs. Fellow students included Gilberto Hernández Ortega and Eligio Pichardo.
In Santo Domingo, she worked closely with other important Dominican artists, including Gilberto Hernández Ortega, Josep Gausachs and Jaime Colson. In 1955, she was named vice director of the National School of Fine Arts.
In 1961, Ledesma and her husband, Terrazas, moved to New York City, New York, where she opened another gallery. She lived and worked in New York City the rest of her life.
Ledesma's style ranged from Expressionism and Surrealism to Abstraction.
She is known for her use of brilliant colors, imaginative figures and the feeling of magic and mysticism created in her paintings and drawings. In 1955, journalist Horia Tanasescu described her work, "At times ironic, often playful, but taking great care in the production of her paintings, this artist introduces an enthusiasm for life to the national art scene that is in striking contrast to the solemnity of the majority of her fellow artists."Wikipedia