Between 1930 and 1934, he took several trips to Greece, Turkey, Palestine and Egypt, either together with Gala Galaction and his daughters, or with his own fiancée, Maria Fotiade (whom he married on May 5, 1935). It was during these trips that he retook to painting, being inspired by the Mediterranean landscapes.
With the exception of the war period, when he was drafted into the Romanian Army as a combat medic, the practice of medicine did not take up much of his time. Biology had become his second most important interest, and he worked as a scientific researcher within the Romanian Academy. An autodidact in painting, Ţuculescu worked intensely after his second debut. Although he was continuously present in the artistic life of the time, his work found almost no response.
He died in Bucharest at the age of 52, and was buried in the Cernica monastery graveyard, in the Galaction family vault.